UAP56 Rabbit Polyclonal Antibody

About this product

Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.

Specifications

Catalog number

HA500102

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

0610030D10Rik antibody 4F2-LC6 antibody 56 kDa U2AF65-associated protein antibody AI428441 antibody ATP-dependent RNA helicase p47 antibody B (0,+)-type amino acid transporter 1 antibody BAT1 antibody Bat1a antibody D17H6S81E antibody D17H6S81E-1 antibody D6S81E antibody D6S81Eh antibody DDX39B antibody DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B antibody DEAD box protein UAP56 antibody DX39B_HUMAN antibody EC 3.6.1.- antibody Glycoprotein-associated amino acid transporter b0,+AT1 antibody HLA-B-associated transcript 1 protein antibody HLA-B-associated transcript 1A antibody HLA-B-associated transcript-1 antibody MGC127051 antibody MGC19235 antibody MGC38799 antibody nuclear RNA helicase (DEAD family) antibody OTTHUMP00000029229 antibody OTTHUMP00000165889 antibody OTTHUMP00000165890 antibody p47 antibody Solute carrier family 7 member 9 antibody Spliceosome RNA helicase BAT1 antibody Spliceosome RNA helicase DDX39B antibody U2AF65-associayed protein, 56-KD antibody UAP56 antibody

Abbreviation

Spliceosome RNA helicase DDX39B 56 kDa U2AF65-associated protein ATP-dependent RNA helicase p47 DEAD box protein UAP56 HLA-B-associated transcript 1 protein

Swiss Prot

Q13838 Human, Q9Z1N5 Mouse, Q63413 Rat

Cellular Locus

Cytoplasm, Nucleus, Spliceosome.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human UAP56 aa 100-300.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

293 cell lysate, Hela cell lysate, rat bladder tissue, rat kidney tissue, human breast tissue, human esophagus tissue, mouse testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:100-1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

49 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No