IGF1 (E peptide) Rabbit Polyclonal Antibody

About this product

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca (2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1.

Specifications

Catalog number

HA500107

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

IBP1 antibody IGF I antibody IGF IA antibody IGF IB antibody IGF-I antibody Igf1 antibody IGF1_HUMAN antibody IGF1A antibody IGFI antibody IGFIA antibody Insulin like growth factor 1 (somatomedin C) antibody Insulin like growth factor 1 antibody Insulin like growth factor IA antibody Insulin like growth factor IB antibody Insulin-like growth factor I antibody Mechano growth factor antibody MGF antibody OTTHUMP00000195080 antibody OTTHUMP00000195081 antibody OTTHUMP00000195082 antibody OTTHUMP00000195083 antibody OTTHUMP00000195084 antibody Somatomedia C antibody Somatomedin C antibody Somatomedin-C antibody

Abbreviation

IGF1

Swiss Prot

P05019 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human IGF1 aa 130-170.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Hela cell lysate, SW480 cell lysate, human liver tissue, K562.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:200-1:1000 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No