Activin Receptor Type IA Rabbit Polyclonal Antibody

About this product

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Specifications

Catalog number

HA500117

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Activin A receptor type I antibody Activin A receptor type II like kinase 2 antibody Activin receptor type I antibody Activin receptor type-1 antibody Activin receptor-like kinase 2 antibody ACTR-I antibody ACTRI antibody Acvr1 antibody ACVR1_HUMAN antibody ACVR1A antibody ACVRLK2 antibody ALK 2 antibody ALK-2 antibody ALK2 antibody FOP antibody Hydroxyalkyl protein kinase antibody Serine/threonine-protein kinase receptor R1 antibody SKR1 antibody TGF-B superfamily receptor type I antibody TGFB superfamily receptor type I antibody TSR-I antibody TSRI antibody

Abbreviation

ACVR1

Swiss Prot

Q04771 Human, P37172 Mouse, P80201 Rat

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human Activin Receptor Type IA aa 440-480.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

Mouse skeletal muscle tissue lysate, PC-3 cell lysate, rat skeletal muscle tissue lysate, MG-63.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

57 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No