PAI1 Rabbit Polyclonal Antibody

About this product

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair). It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

Catalog number

HA500124

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Clade E antibody Endothelial plasminogen activator inhibitor antibody Nexin antibody Nexin plasminogen activator inhibitor type 1 antibody PAI 1 antibody PAI antibody PAI-1 antibody PAI1_HUMAN antibody PLANH1 antibody Plasminogen activator inhibitor 1 antibody Plasminogen activator inhibitor type 1 antibody Serine (or cysteine) proteinase inhibitor antibody Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody Serine proteinase inhibitor clade E member 1 antibody serpin antibody Serpin E1 antibody Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 antibody Serpin peptidase inhibitor clade E antibody Serpine 1 antibody SERPINE1 antibody

Abbreviation

SERPINE1

Swiss Prot

P05121 Human, P22777 Mouse, P20961 Rat

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human PAI1 aa 40-80.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

Rat brain tissue lysate, rat cerebellum tissue lysate, MG-63, SiHa, human placenta tissue, mouse kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

45 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No