GNB3 Rabbit Polyclonal Antibody

About this product

Heterotrimeric guanine nucleotide-binding proteins ( G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

Specifications

Catalog number

HA500127

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

G protein beta 3 subunit antibody GBB3_HUMAN antibody GNB3 antibody GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 antibody GTP binding regulatory protein beta 3 chain antibody Guanine nucleotide binding protein (G protein) beta polypeptide 3 antibody Guanine nucleotide binding protein G antibody Guanine nucleotide binding protein G (I)/G (S)/G (T) beta subunit 3 antibody Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-3 antibody Hypertension associated protein antibody IG antibody SG antibody Transducin beta chain 3 antibody Tsubunit beta 3 antibody

Abbreviation

Guanine nucleotide-binding protein G (I)/G (S)/G (T) subunit beta-3 Transducin beta chain 3

Swiss Prot

P16520 Human, Q61011 Mouse, P52287 Rat

Cellular Locus

Cytosol, Extracellular region or secreted, Plasma Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human GNB3 aa 100-150.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P

Positive Control

HepG2 cell lysate, A549 cell lysate, mouse kidney tissue lysate, rat brian tissue lysate, F9, rat kidney tissue, mouse brian tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

37 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No