THOC5 Rabbit Polyclonal Antibody

About this product

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.

Specifications

Catalog number

HA500129

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

C22orf19 antibody Chromosome 22 open reading frame 19 antibody Fmip antibody Fms interacting protein antibody fSAP79 antibody Functional spliceosome-associated protein 79 antibody hTREX90 antibody KIAA0983 antibody LOC400922 antibody NF2/meningioma region protein pK1.3 antibody PK1.3 antibody Placental protein 39.2 antibody PP39.2 antibody THO complex 5 antibody THO complex subunit 5 antibody THO complex subunit 5 homolog antibody thoc5 antibody THOC5_HUMAN antibody

Abbreviation

THOC5

Swiss Prot

Q13769 Human, Q8BKT7 Mouse, Q68FX7 Rat

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human THOC5 aa 1-200.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

NIH/3T3 cell lysate, PC-12 cell lysate, Hela cell lysate, HepG2 cell lysate, human ovarian tumor tissue, mouse brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

79 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No