D4 GDI Rabbit Polyclonal Antibody

About this product

The Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to proliferation, cytoskeletal organization and secretion. The counter-conversion of the active GTP-bound form of these proteins to their inactive GDP-bound form is influenced by two types of regulatory proteins: those that alter the intrinsic GTPase activity of the GTP-binding proteins and those that alter the rate of GDP/GTP exchange. Guanine nucleotide-releasing factors (GRFs) increase the GDP dissociation rate, while GDP-dissociation inhibitors (GDIs) decrease the dissociation rate. The Rho GDI subfamily is composed of Rho GDIα, Ly-GDI (also known as Rho GDIβ and previously known as GDI/D4) and Rho GDIγ. The Rho GDI proteins interact with and have varying affinities for several Ras-like GTP binding proteins, including Rho A, Rho B, Rac and Cdc42. Ly-GDI is expressed only in hematopoietic cells, predominantly in B and T lymphocyte cell lines.

Specifications

Catalog number

HA500217

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Arhgdib antibody D4 antibody D4 GDP dissociation inhibitor antibody GDIA 2 antibody GDIA2 antibody GDID 4 antibody GDID4 antibody GDIR2_HUMAN antibody GDP dissociation inhibitor D4 antibody LY GDI antibody Ly-GDI antibody LYGDI antibody MGC108926 antibody RAP1GN1 antibody Rho GDI 2 antibody Rho GDI beta antibody Rho GDI2 antibody Rho GDP dissociation inhibitor (GDI) beta antibody Rho GDP dissociation inhibitor 2 antibody Rho GDP dissociation inhibitor beta antibody Rho GDP-dissociation inhibitor 2 antibody Rho-GDI beta antibody RhoGDI2 antibody

Abbreviation

D4 GDI

Swiss Prot

P52566 Human, Q61599 Mouse,

Cellular Locus

Cytosol.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within C-terminal human D4 GDI from aa65-aa201.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

Jurkat cell lysate, U937 cell lysate, HL-60 cell lysate, rat spleen tissue lysate, mouse spleen tissue lysate, human colon tissue, human tonsil tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:100-1:500 ;IF-Cell: 1:50-1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 23 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No