Presenilin 1/PS-1 Rabbit Polyclonal Antibody — image 1 of 3

Product details

Presenilin 1/PS-1 Rabbit Polyclonal Antibody

Catalog number HA500219

Price for HA500219

Size / count 100 µL

About this product

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Specifications

Catalog number: HA500219
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: AD3 antibody Ad3h antibody FAD antibody Homo Sapiens Clone CC44 Senilin 1 antibody Presenilin-1 CTF12 antibody Protein S182 antibody PS 1 antibody PS-1 antibody PS1-CTF12 antibody PSEN1 antibody PSN1_HUMAN antibody PSNL1 antibody S182 antibody
Abbreviation: PSEN1
Swiss Prot: P49768 Human, P49769 Mouse, P97887 Rat
Cellular Locus: Endoplasmic reticulum, Endoplasmic reticulum membrane, Golgi apparatus membrane, Cell membrane, Early endosome, Early endosome membrane, Cytoplasmic granule, growth cone, neuron projection, axon, synapse.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within human Presenilin 1 aa 330-380.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC, IHC-Fr, IF-Tissue
Positive Control: NIH/3T3 cell lysate, Raji cell lysate, MCF-7 cell lysate, Daudi cell lysate, mouse liver tissue lysate, rat liver tissue lysate, MCF-7, human small intestine tissue, mouse testis tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:500 ;FC: 1:500-1:1,000 ;IHC-Fr: 1:100 ;IF-Tissue: 1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 53 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Presenilin 1/PS-1 Rabbit Polyclonal Antibody?

The catalog number for Presenilin 1/PS-1 Rabbit Polyclonal Antibody is HA500219.

What sizes are available for Presenilin 1/PS-1 Rabbit Polyclonal Antibody?

Presenilin 1/PS-1 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Presenilin 1/PS-1 Rabbit Polyclonal Antibody in stock?

Presenilin 1/PS-1 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Presenilin 1/PS-1 Rabbit Polyclonal Antibody used for?

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.

Is this kit compatible with automated liquid handling platforms?

Automation compatibility varies by kit and isn’t always listed on the datasheet. Contact our technical support team with details of your platform so we can confirm with the manufacturer.

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.