BTNL3 Rabbit Polyclonal Antibody

About this product

Butyrophilin-like 3 (BTNL3) is a member of the BTN/MOG Ig-superfamily which is coded by the BTNL3 gene, also known as COLF4100. BTNL3 is a 466 amino acid (aa) type I transmembrane protein that contains a 220 aa extracellular domain (ECD), a 21 aa helical transmembrane domain, and a 208 aa cytoplasmic domain. The ECD features both an IgV and IgC domain, which is commonplace in BTN/BTNL proteins, but the IgC domain is relatively weak. The ECD of human BTNL3 shares only 37% and 34% aa sequence identity with mouse (referred to as BTNL1) and rat, respectively. Human BTNL3 mRNA has been identified in many tissues including small intestine, colon, liver, lung, bone marrow and spleen tissue, and it is highly expressed in neutrophils. BTNL3 expression has also been found to be down-regulated in colon cancer tumors. The specific function of BTNL3, however, has yet to be fully elucidated. R&D in house data indicate that BTNL3 protein inhibits the secretion of IFN-gamma from anti-CD3 activated human T cells.

Specifications

Catalog number

HA500239

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

BTNL3 antibody BTNL3_HUMAN antibody BTNLR antibody Butyrophilin like protein 3 antibody Butyrophilin like receptor antibody Butyrophilin-like protein 3 antibody Butyrophilin-like receptor antibody COLF4100 antibody

Abbreviation

BTNL3

Swiss Prot

Q6UXE8 Human

Cellular Locus

Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within human BTNL3 aa 150-200.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

Jurkat cell lysate, K562 cell lysate, HL-60 cell lysate, human spleen tissue, human small intestine tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:100-1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 52 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No