IL-10RA Rabbit Polyclonal Antibody — image 1 of 3

Product details

IL-10RA Rabbit Polyclonal Antibody

Catalog number HA500251

Price for HA500251

Size / count 100 µL

About this product

Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.

Specifications

Catalog number: HA500251
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CD210 antibody CDw210a antibody CDw210a antigen antibody HIL 10R antibody HIL10R antibody I10R1_HUMAN antibody IL 10R 1 antibody IL 10R A antibody IL 10R antibody IL 10R1 antibody IL-10 receptor subunit alpha antibody IL-10R subunit 1 antibody IL-10R subunit alpha antibody IL-10R1 antibody IL-10RA antibody IL10R antibody IL10R1 antibody IL10RA antibody Interleukin 10 receptor alpha antibody Interleukin 10 receptor alpha chain antibody Interleukin-10 receptor subunit 1 antibody Interleukin-10 receptor subunit alpha antibody
Abbreviation: IL10RA
Swiss Prot: Q13651 Human
Cellular Locus: Cytoplasm, Cell membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human IL-10RA aa 491-540/578.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P, IF-Cell
Positive Control: Daudi cell lysates, Jurkat cell lysate, THP-1 cell lysate, MCF-7 cell lysate, human tonsil tissue, SiHa.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000;IHC-P: 1:200-1:1,000;IF-Cell: 1:50-1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 63 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for IL-10RA Rabbit Polyclonal Antibody?

The catalog number for IL-10RA Rabbit Polyclonal Antibody is HA500251.

What sizes are available for IL-10RA Rabbit Polyclonal Antibody?

IL-10RA Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is IL-10RA Rabbit Polyclonal Antibody in stock?

IL-10RA Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is IL-10RA Rabbit Polyclonal Antibody used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.