2B4 Rabbit Polyclonal Antibody

About this product

Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor . Activating function implicates association with SH2D1A and FYN . Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis . Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells. Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells. Involved in the regulation of CD8+ T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells. Inhibits inflammatory responses in dendritic cells (DCs) .

Specifications

Catalog number

HA500263

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

2B4 antibody C9.1 antibody CD244 antibody CD244 antigen antibody CD244 molecule antibody CD244 molecule natural killer cell receptor 2B4 antibody CD244 natural killer cell receptor 2B4 antibody CD244_HUMAN antibody F730046O15Rik antibody h2B4 antibody Ly90 antibody NAIL antibody Natural killer cell activation-inducing ligand antibody Natural killer cell receptor 2B4 antibody NK cell activation inducing ligand antibody NK cell activation inducing ligand NAIL antibody NK cell activation-inducing ligand antibody NK cell type I receptor protein 2B4 antibody NKR2B4 antibody Nmrk antibody Non-MHC restricted killing associated antibody OTTHUMP00000027884 antibody p38 antibody signaling lymphocytic activation molecule 4 antibody SLAM family, member 4 antibody SLAMF4 antibody

Abbreviation

Natural killer cell receptor 2B4 NK cell activation-inducing ligand NAIL NK cell type I receptor protein 2B4 NKR2B4 h2B4 SLAM family member 4 SLAMF4 Signaling lymphocytic activation molecule 4 CD244

Swiss Prot

Q9BZW8 Human, Q9JLM2 Rat

Cellular Locus

Cell membrane, Membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic peptide within human 2B4 aa 330-370 / 370 (Cytoplasmic).

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB

Positive Control

U937 cell lysate, rat brain tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

66 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No