TEAD1 Rabbit Polyclonal Antibody

About this product

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Specifications

Catalog number

HA500277

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AA antibody Atrophia areata peripapillary chorioretinal degeneration antibody NTEF 1 antibody NTEF-1 antibody NTEF1 antibody Protein GT IIC antibody Protein GT-IIC antibody REF 1 antibody REF1 antibody SV40 transcriptional enhancer factor antibody TCF 13 antibody TCF-13 antibody TCF13 antibody TEA domain family member antibody TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody TEA domain family member 1 antibody TEAD 1 antibody TEAD 1 protein antibody TEAD-1 antibody TEAD1 antibody TEAD1 protein antibody TEAD1_HUMAN antibody TEF 1 antibody TEF1 antibody Transcription factor 13 (SV40 transcriptional enhancer factor) antibody Transcription factor 13 antibody Transcriptional enhancer factor 1 antibody Transcriptional enhancer factor TEF-1 antibody Transcriptional enhancer factor TEF1 antibody

Abbreviation

TEAD1

Swiss Prot

P28347 Human, P30051 Mouse,

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human TEAD1 aa 1-150 / 426.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Mouse liver tissue lysate, mouse skeletal muscle tissue lysate, rat skeletal muscle tissue, human fetal skeletal muscle tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:400 ;FC: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 48 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No