Triosephosphate isomerase Rabbit Polyclonal Antibody

About this product

Triose-phosphate isomerase (TPI or TIM) is an enzyme (EC 5.3.1.1) that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. Compound C00111 at KEGG Pathway Database.Enzyme 5.3.1.1 at KEGG Pathway Database.Compound C00118 at KEGG Pathway Database. TPI plays an important role in glycolysis and is essential for efficient energy production. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants, and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI. In humans, deficiencies in TPI are associated with a progressive, severe neurological disorder called triose phosphate isomerase deficiency. Triose phosphate isomerase deficiency is characterized by chronic hemolytic anemia. While there are various mutations that cause this disease, most include the mutation of glutamic acid at position 104 to aspartic acid. Triose phosphate isomerase is a highly efficient enzyme, performing the reaction billions of times faster than it would occur naturally in solution. The reaction is so efficient that it is said to be catalytically perfect: It is limited only by the rate the substrate can diffuse into and out of the enzyme's active site.

Specifications

Catalog number

HA500283

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

epididymis secretory protein Li 49 antibody HEL-S-49 antibody MGC88108 antibody TIM antibody TPI 1 antibody TPI antibody TPI1 antibody TPID antibody Triose phosphate isomerase 1 antibody Triose phosphate isomerase antibody Triosephosphate isomerase 1 antibody Triosephosphate isomerase antibody

Abbreviation

TPI1

Swiss Prot

P60174 Human, P17751 Mouse, P48500 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human Triosephosphate isomerase aa 1-200 / 249.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

Rat brain tissue lysate, 293 cell lysate, HepG2 cell lysate, rat skeletal muscle tissue lysate, mouse skeletal muscle tissue lysate, mouse lung tissue lysate, human colon tissue, mouse liver tissue, 293T.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:400 ;FC: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 27 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No