TAZ Rabbit Polyclonal Antibody

About this product

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation . In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation . Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Specifications

Catalog number

HA500300

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

DKFZP586I1419 antibody FLJ27004 antibody FLJ45718 antibody OTTHUMP00000215994 antibody OTTHUMP00000215995 antibody OTTHUMP00000215996 antibody OTTHUMP00000216001 antibody TAZ antibody Transcriptional co activator with PDZ binding motif antibody Transcriptional coactivator with PDZ binding motif antibody Transcriptional coactivator with PDZ-binding motif antibody WW domain containing transcription regulator 1 antibody WW domain containing transcription regulator protein 1 antibody WW domain-containing transcription regulator protein 1 antibody WWTR 1 antibody WWTR1 antibody WWTR1_HUMAN antibody

Abbreviation

WW domain-containing transcription regulator protein 1 Transcriptional coactivator with PDZ-binding motif

Swiss Prot

Q9GZV5 Human, Q9EPK5 Mouse

Cellular Locus

Cell membrane, Cytoplasm, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within human TAZ aa 1-200 / 400.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

Human placenta tissue lysate, 293T cell lysate, human kidney tissue, mouse brain tissue, A549, HT-29.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IHC-P: 1:100-1:500;IF-Cell: 1:100-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No