GRK3 Rabbit Polyclonal Antibody

About this product

G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an arrestin protein to the receptor. Arrestin binding to phosphorylated, active receptor prevents receptor stimulation of heterotrimeric G protein transducer proteins, blocking their cellular signaling and resulting in receptor desensitization. Arrestin binding also directs receptors to specific cellular internalization pathways, removing the receptors from the cell surface and also preventing additional activation. Arrestin binding to phosphorylated, active receptor also enables receptor signaling through arrestin partner proteins. Thus the GRK/arrestin system serves as a complex signaling switch for G protein-coupled receptors.

Specifications

Catalog number

HA500317

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

ADRBK2 antibody Adrenergic, beta, receptor kinase 2 antibody ARBK2_HUMAN antibody BARK2 antibody Beta adrenergic receptor kinase 2 antibody Beta ARK 2 antibody Beta-adrenergic receptor kinase 2 antibody Beta-ARK-2 antibody EC 2.7.11.15 antibody G protein coupled receptor kinase 3 antibody G-protein-coupled receptor kinase 3 antibody GRK3 antibody

Abbreviation

Beta-adrenergic receptor kinase 2 Beta-ARK-2 G-protein-coupled receptor kinase 3

Swiss Prot

P35626 Human, P26819 Rat

Cellular Locus

cytosol, plasma membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant protein within human GRK3 aa 450-688 / 688.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

Jurkat cell lysate, SHSY5Y cell lysate, HL-60 cell lysate, rat stomachl tissue lysate, MG-63, SiHa, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:1,000;IF-Cell: 1:50-1:200;FC: 1:500-1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 80 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No