IL-12RB2 Rabbit Polyclonal Antibody — image 1 of 3

Product details

IL-12RB2 Rabbit Polyclonal Antibody

Catalog number HA500320

Price for HA500320

Size / count 100 µL

About this product

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The co-expression of this and IL12Rβ1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. While the IL12Rβ1 subunit is constitutively expressed, the expression of the IL12RB2 gene is up-regulated by interferon gamma. In Th1 cells, IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Specifications

Catalog number: HA500320
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: I12R2_HUMAN antibody IL-12 receptor subunit beta-2 antibody IL-12R subunit beta-2 antibody IL-12R-beta-2 antibody IL-12RB2 antibody IL12 receptor beta 2 antibody IL12R beta2 antibody IL12RB2 antibody Interleukin 12 receptor beta 2 antibody Interleukin 12 receptor beta 2 chain antibody Interleukin-12 receptor subunit beta-2 antibody RP11 102M16.1 antibody
Abbreviation: IL12RB2
Swiss Prot: Q99665 Human
Cellular Locus: Membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human IL-12RB2 aa 751-800.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: HepG2 cell lysate, 293T cell lysate, Hela, human placenta tissue, THP-1.
Concentration: 1 mg/mL
Dilution: WB: 1:500;IF-Cell: 1:200;IHC-P: 1:600;FC: 1:500-1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 97 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for IL-12RB2 Rabbit Polyclonal Antibody?

The catalog number for IL-12RB2 Rabbit Polyclonal Antibody is HA500320.

What sizes are available for IL-12RB2 Rabbit Polyclonal Antibody?

IL-12RB2 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is IL-12RB2 Rabbit Polyclonal Antibody in stock?

IL-12RB2 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is IL-12RB2 Rabbit Polyclonal Antibody used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.