PERK Rabbit Polyclonal Antibody

Catalog number HA500326

Price for HA500326

Size / count 100 µL

About this product

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

Specifications

Catalog number: HA500326
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: DKFZp781H1925 antibody E2AK3_HUMAN antibody EC 2.7.11.1 antibody Eif2ak3 antibody Eukaryotic translation initiation factor 2 alpha kinase 3 antibody Eukaryotic translation initiation factor 2-alpha kinase 3 antibody Heme regulated EIF2 alpha kinase antibody HRI antibody HsPEK antibody Pancreatic eIF2 alpha kinase antibody Pancreatic eIF2-alpha kinase antibody PEK antibody PRKR like endoplasmic reticulum kinase antibody PRKR-like endoplasmic reticulum kinase antibody WRS antibody
Abbreviation: EIF2AK3
Swiss Prot: Q9NZJ5 Human
Cellular Locus: Endoplasmic reticulum membrane.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within human PERK aa 1,067-1,116/1,116.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB
Positive Control: MCF-7 cell lysate, 293 cell lysate, HepG2 cell lysate, Hela cell lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 125 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for PERK Rabbit Polyclonal Antibody?

The catalog number for PERK Rabbit Polyclonal Antibody is HA500326.

What sizes are available for PERK Rabbit Polyclonal Antibody?

PERK Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is PERK Rabbit Polyclonal Antibody in stock?

PERK Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is PERK Rabbit Polyclonal Antibody used for?

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.