GRB7 Rabbit Polyclonal Antibody

Catalog number HA500328

Price for HA500328

Size / count 100 µL

About this product

Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7, thought to be involved in migration[citation needed], is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.

Specifications

Catalog number: HA500328
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: B47 antibody Epidermal growth factor receptor GRB 7 antibody Epidermal growth factor receptor GRB-7 antibody GRB7 adapter protein antibody GRB7 antibody GRB7_HUMAN antibody Growth factor receptor bound protein 7 antibody Growth factor receptor-bound protein 7 antibody OTTHUMP00000164349 antibody OTTHUMP00000164350 antibody OTTHUMP00000164351 antibody OTTHUMP00000164352 antibody
Abbreviation: GRB7
Swiss Prot: Q14451 Human
Cellular Locus: Cell membrane, Cytoplasm, Focal adhesion, Cytoplasmic granule, Cell projection.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within human GRB7 aa 1-200/532.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB
Positive Control: SK-Br-3 cell lysates.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000-1:5,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 60 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for GRB7 Rabbit Polyclonal Antibody?

The catalog number for GRB7 Rabbit Polyclonal Antibody is HA500328.

What sizes are available for GRB7 Rabbit Polyclonal Antibody?

GRB7 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is GRB7 Rabbit Polyclonal Antibody in stock?

GRB7 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is GRB7 Rabbit Polyclonal Antibody used for?

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.