PSMB7 Rabbit Polyclonal Antibody

About this product

Proteasome subunit beta type-7 as known as 20S proteasome subunit beta-2 is a protein that in humans is encoded by the PSMB7 gene. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future. The proteasomes form a pivotal component for the ubiquitin–proteasome system (UPS) and corresponding cellular Protein Quality Control (PQC). Protein ubiquitination and subsequent proteolysis and degradation by the proteasome are important mechanisms in the regulation of the cell cycle, cell growth and differentiation, gene transcription, signal transduction and apoptosis. Subsequently, a compromised proteasome complex assembly and function lead to reduced proteolytic activities and the accumulation of damaged or misfolded protein species. Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, cardiovascular diseases, inflammatory responses and autoimmune diseases, and systemic DNA damage responses leading to malignancies.

Specifications

Catalog number

HA500345

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Macropain chain Z antibody Multicatalytic endopeptidase complex chain Z antibody Proteasome (prosome macropain) subunit beta type 7 antibody Proteasome beta 7 subunit antibody Proteasome catalytic subunit 2 antibody Proteasome subunit alpha antibody Proteasome subunit beta 7 antibody Proteasome subunit beta type-7 antibody Proteasome subunit Z antibody PSB7_HUMAN antibody PSMB7 antibody PUP1 antibody Z antibody

Abbreviation

PSMB7

Swiss Prot

Q99436 Human

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human PSMB7 aa 1-277 / 277.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

SW480 cell lysate, HepG2 cell lysate, Hela cell lysate, human lung carcinoma tissue, human colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IHC-P: 1:600

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 30 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No