Calcineurin B Rabbit Polyclonal Antibody

About this product

Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus. Calcineurin inhibitors are prescribed for adult rheumatoid arthritis (RA) as a single drug or in combination with methotrexate. The microemulsion formulation is approved by the U.S. Food and Drug Administration for treatment of severely active RA. Calcineurin is linked to receptors for several brain chemicals including glutamate, dopamine and GABA. Calcineurin along with NFAT, may improve the function of diabetics' pancreatic beta cells. Calcineurin inhibitors such as tacrolimus are used to suppress the immune system in organ allotransplant recipients to prevent rejection of the transplanted tissue.

Specifications

Catalog number

HA500346

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

alpha isoform (calcineurin B, type I) antibody calcineurin B, type I (19kDa) antibody Calcineurin subunit B type 1 antibody CALNB1 antibody CANB1_HUMAN antibody Cna2 antibody CNB antibody CNB1 antibody OTTHUMP00000201960 antibody OTTHUMP00000201961 antibody Ppp3r1 antibody PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform antibody protein phosphatase3 (formerly2B), regulatory subunit B, alpha isoform antibody Protein phosphatase 2B regulatory subunit 1 antibody Protein phosphatase 2B regulatory subunit B alpha antibody protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) antibody Protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) antibody Protein phosphatase 3 regulatory subunit B alpha antibody Protein phosphatase 3 regulatory subunit B alpha isoform 1 antibody

Abbreviation

PPP3R1

Swiss Prot

P63098 Human, Q63810 Mouse, P63100 Rat

Cellular Locus

Cell membrane, sarcolemma, cell membrane, cytosol.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Calcineurin B aa 1-170 / 170.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Rat brain tissue lysate, mouse brain tissue lysate, SiHa, rat brain tissue, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:200;IHC-P: 1:600;FC: 1:500-1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 19 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No