TMED5 Rabbit Polyclonal Antibody

Catalog number HA500347

Price for HA500347

Size / count 100 µL

About this product

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport. TMED5 is a part of the p24 protein family whose general functions are protein trafficking for the secretory pathway. TMED5 is thought to be necessary in the formation of the Golgi into a ribbon. Glycosylphosphatidylinositol-anchored proteins (GPI-AP) depend on p24 cargo receptors for transport from the ER to the Golgi. Knockdown of p24γ2 (a mouse ortholog of TMED5) in mice resulted in impaired transport of GPI-AP. The study concluded that the α-helical region of p24γ2 binds GPI which is necessary to incorporate it into COPII transport vesicles. TMED5 is reported to be necessary for the secretion of Wnt ligands. TMED5 has been found to interact with WNT7B, activating the canonical WNT-CTNNB1/β-catenin signaling pathway. This pathway is linked to numerous cancers because upregulation of the Wnt/β-catenin signaling pathway leads to cytosolic accumulation of β-catenin, promoting cellular proliferation.

Specifications

Catalog number: HA500347
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: CGI 100 antibody DKFZp781B2248 antibody p24 family protein gamma-2 antibody p24gamma2 antibody p28 antibody RP5 976O13.2 antibody TMED 5 antibody TMED5 antibody TMED5_HUMAN antibody Transmembrane emp24 domain containing protein 5 antibody Transmembrane emp24 domain-containing protein 5 antibody Transmembrane emp24 protein transport domain containing 5 antibody UNQ397/PRO733 antibody
Abbreviation: TMED5
Swiss Prot: Q9Y3A6 Human, Q9CXE7 Mouse, Q6AXN3 Rat
Cellular Locus: Cis-Golgi network membrane, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within Human TMED5 aa 1-200 / 229.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P
Positive Control: Rat liver tissue lysate, A431 cell lysate, Jurkat cell lysate, Hela cell lysate, SiHa cell lysate, rat bladder tissue, mouse large intestine tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500 ;IHC-P: 1:600-1:5,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 26 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for TMED5 Rabbit Polyclonal Antibody?

The catalog number for TMED5 Rabbit Polyclonal Antibody is HA500347.

What sizes are available for TMED5 Rabbit Polyclonal Antibody?

TMED5 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is TMED5 Rabbit Polyclonal Antibody in stock?

TMED5 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is TMED5 Rabbit Polyclonal Antibody used for?

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Is this product covered by a money-back guarantee?

Yes, we guarantee a full refund or store credit if this product arrives damaged beyond usability, or has a genuine performance issue under proper usage and storage, provided you report it immediately with evidence. Claims after the expiration date or due to improper storage after receipt are excluded.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.