PSMC5 Rabbit Polyclonal Antibody

About this product

26S protease regulatory subunit 8, also known as 26S proteasome AAA-ATPase subunit Rpt6, is an enzyme that in humans is encoded by the PSMC5 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits (Rpt1, Rpt2, Rpt3, Rpt4, Rpt5, and Rpt6 (this protein)) together with four non-ATPase subunits (Rpn1, Rpn2, Rpn10, and Rpn13) form the base sub complex of 19S regulatory particle for proteasome complex. As the degradation machinery that is responsible for ~70% of intracellular proteolysis, proteasome complex (26S proteasome) plays a critical roles in maintaining the homeostasis of cellular proteome. Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in parallel, some key regulatory proteins fulfill their biological functions via selective degradation; furthermore, proteins are digested into peptides for MHC class I antigen presentation. To meet such complicated demands in biological process via spatial and temporal proteolysis, protein substrates have to be recognized, recruited, and eventually hydrolyzed in a well controlled fashion. Thus, 19S regulatory particle pertains a series of important capabilities to address these functional challenges. To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special degradative tag, the ubiquitinylation. It also have subunits that can bind with nucleotides (e.g., ATPs) in order to facilitate the association between 19S and 20S particles, as well as to cause confirmation changes of alpha subunit C-terminals that form the substate entrance of 20S complex.

Specifications

Catalog number

HA500352

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

26S protease regulatory subunit 8 antibody 26S proteasome AAA-ATPase subunit RPT6 antibody Cim3 antibody MSUG1 protein antibody p45 antibody p45/SUG antibody Proteasome 26S ATPase subunit 5 antibody Proteasome 26S subunit ATPase 5 antibody Proteasome prosome macropain 26S subunit ATPase 5 antibody Proteasome subunit p45 antibody PRS8_HUMAN antibody PSMC5 antibody Rpt6 antibody S8 antibody SUG1 antibody Tat binding protein homolog 10 antibody TBP10 antibody Thyroid hormone receptor interacting protein 1 antibody Thyroid hormone receptor-interacting protein 1 antibody Thyroid receptor interactor 1 antibody TRIP1 antibody TRIP1 (SUG1) antibody

Abbreviation

PSMC5

Swiss Prot

P62195 Human, P62196 Mouse, P62198 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human PSMC5 aa 205-406 / 406.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

MCF-7 cell lysate, Hela cell lysate, 293T cell lysate, mouse heart tissue lysate, mouse brain tissue lysate, rat testis tissue lysate, rat brain tissue, human colon tissue, human skin tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:1,500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 46 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No