TIP49A Rabbit Polyclonal Antibody

About this product

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation.

Specifications

Catalog number

HA500355

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

49 kDa TATA box binding protein interacting protein antibody 49 kDa TATA box-binding protein-interacting protein antibody 49 kDa TBP interacting protein antibody 49 kDa TBP-interacting protein antibody 54 kDa erythrocyte cytosolic protein antibody ECP-54 antibody ECP54 antibody ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD antibody INO80 complex subunit H antibody NMP 238 antibody Nuclear matrix protein 238 antibody Pontin 52 antibody PONTIN antibody RuvB like 1 antibody RuvB like AAA ATPase 1 antibody RuvB-like 1 antibody RUVB1_HUMAN antibody RUVBL1 antibody RVB1 antibody TAP54 alpha antibody TAP54-alpha antibody TIP49 antibody TIP49a antibody TIP60 associated protein 54 alpha antibody TIP60-associated protein 54-alpha antibody

Abbreviation

RUVBL1

Swiss Prot

Q9Y265 Human, P60122 Mouse, P60123 Rat

Cellular Locus

Cytoplasm, Cytoskeleton, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human TIP49A aa 121-320 / 456.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

Hela cell lysate, MCF-7 cell lysate, NIH/3T3 cell lysate, mouse liver tissue lysate, mouse skeletal muscle tissue lysate, rat skin tissue lysate, Rat skeletal muscle lysate, human liver tissue, human testis tissue, rat trachea tissue, human fallopian tube tissue, mouse skeletal muscle tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:400-1:800

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 50 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No