MPL Rabbit Polyclonal Antibody

Catalog number HA500360

Price for HA500360

Size / count 100 µL

About this product

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin, CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Specifications

Catalog number: HA500360
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: C MPL antibody CD110 antibody mpl antibody MPLV antibody Myeloproliferative leukemia protein antibody Myeloproliferative leukemia virus oncogene antibody Proto-oncogene c-Mpl antibody THCYT2 antibody Thrombopoietin receptor antibody TPO R antibody TPO-R antibody TPOR antibody TPOR_HUMAN antibody
Abbreviation: MPL
Swiss Prot: P40238 Human
Cellular Locus: Cell membrane, Golgi apparatus, Cell surface.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human MPL aa 551-600 / 635.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IF-Cell, IHC-P
Positive Control: A549 cell lysate, Raji cell lysate, THP-1 cell lysate, SH-SY5Y, human placenta tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000;IF-Cell: 1:200;IHC-P: 1:200
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 71 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for MPL Rabbit Polyclonal Antibody?

The catalog number for MPL Rabbit Polyclonal Antibody is HA500360.

What sizes are available for MPL Rabbit Polyclonal Antibody?

MPL Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is MPL Rabbit Polyclonal Antibody in stock?

MPL Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is MPL Rabbit Polyclonal Antibody used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.