YWHAZ Rabbit Polyclonal Antibody

About this product

14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways. 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases. As a major hub protein, 14-3-3ζ is involved in various diseases and disorders. For one, 14-3-3ζ plays a central role in cell proliferation and, by extension, tumor progression. The protein has been implicated in many cancers, including lung cancer, breast cancer, lymphoma, and head and neck cancer, through pathways such as mTOR, Akt, and glucose receptor trafficking. Notably, it has been associated with chemoresistance and, thus, is a promising therapeutic target for cancer treatment. So far, it stands to become a prognostic marker for breast cancer, lung cancer, head and neck cancer, and possibly gastric cancer in patients who might require more aggressive treatment. In addition to cancers, 14-3-3ζ has been implicated in pathogenic infections and neurodegenerative diseases, including Creutzfeldt–Jakob disease, Parkinson’s disease, and Alzheimer’s disease (AD). 14-3-3ζ has been observed to participate in AD through its interaction with tau protein, and its expression is correlated with disease severity.

Specifications

Catalog number

HA500368

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

14-3-3 protein zeta/delta antibody Protein kinase C inhibitor protein 1 antibody KCIP-1 antibody YWHAZ antibody

Abbreviation

14-3-3 protein zeta/delta Protein kinase C inhibitor protein 1 KCIP-1 YWHAZ

Swiss Prot

P63104 Human, P63101 Mouse,

Cellular Locus

Cytoplasm

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human YWHAZ aa 50-245.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

HepG2 cell lysate, RAW264.7 cell lysate, human kidney tissue lysate, SiHa cell lysate, A549 cell lysate, A375 cell lysate, Hela cell lysate, SH-SY5Y cell lysate, Raji cell lysate, PC-12 cell lysate, mouse lung tissue lysate, rat large intestine tissue, mouse epididymis tissue, mouse testis tissue.

Concentration

1.5 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:600

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 28 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No