RANKL Rabbit Polyclonal Antibody

About this product

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

Specifications

Catalog number

HA500369

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CD254 antibody hRANKL2 antibody ODF antibody OPGL antibody OPTB2 antibody Osteoclast differentiation factor antibody Osteoprotegerin ligand antibody Rank Ligand antibody RANKL antibody Receptor activator of nuclear factor kappa B ligand antibody Receptor activator of nuclear factor kappa-B ligand antibody sOdf antibody TNF related activation induced cytokine antibody TNF-related activation-induced cytokine antibody TNF11_HUMAN antibody TNFSF 11 antibody Tnfsf11 antibody TRANCE antibody Tumor necrosis factor (ligand) superfamily member 11 antibody Tumor necrosis factor ligand superfamily member 11 antibody Tumor necrosis factor ligand superfamily member 11, soluble form antibody

Abbreviation

Tumor necrosis factor ligand superfamily member 11 Osteoclast differentiation factor ODF Osteoprotegerin ligand OPGL Receptor activator of nuclear factor kappa-B ligand RANKL TNF-related activation-induced cytokine TRANCE CD254 TNFSF11 OPGL RANKL TRANCE

Swiss Prot

O14788 Human, O35235 Mouse, Q9ESE2 Rat

Cellular Locus

Cell membrane, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human RANKL aa 100-317.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

Hela cell lysate, mouse spleen tissue lysate, rat spleen tissue lysate, Hela.

Concentration

2 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:100

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 35 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No