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Product details
Catalog number HA500382
Price for HA500382
Size / count 100 µL
PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene. The putative catalytic triad of the protein composed of three aspartic acid residues is conserved among PGBD5-like genes through evolution, and is distinct from other PiggyBac-like genes. PGBD5 has been shown to be able to transpose DNA in a sequence-specific, cut-and-paste fashion. PGBD5 has also been proposed to mediate site-specific DNA rearrangements in human tumors. Human PGBD5 can mobilize the insect PiggyBac transposons in human cell culture. In mature mice brain tissue PGBD5 is found primarily in regions of the olfactory bulb, hippocampus, and cerebellum. In embryonic mice brain tissue PGBD5 is found not only in the medial pallium and prepontine isthmus, which are embryonic brain areas that give rise to the development of the hippocampus and cerebellum but also in areas in the embryonic brain that give rise to the hypothalamus and medulla. PGBD5 is expressed in the majority of human pediatric solid tumors. It's upregulated in sporadic Creutzfeldt-Jakob disease. PGBD5 is associated with frontotemporal dementia, where it gets most expressed in neurons, followed by ogliodendrocytes, mature astrocytes, fetal astrocytes, endothelial cells and then microglia/macrophages.
The catalog number for PGBD5 Rabbit Polyclonal Antibody is HA500382.
PGBD5 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.
PGBD5 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.
PiggyBac Transposable Element Derived 5 is an enzyme that in humans is encoded by the PGBD5 gene. The putative catalytic triad of the protein composed of three aspartic acid residues is conserved among PGBD5-like genes through evolution, and is distinct from other PiggyBac-like genes. PGBD5 has been
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
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