TNFSF14 Rabbit Polyclonal Antibody

About this product

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). Two alternatively spliced transcript variant encoding distinct isoforms have been reported. This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, trigger apoptosis of various tumor cells and play a role in vascular normalisation processes. This protein is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes. Similar to how CD4 is the primary mediating receptor in HIV infection, the HSV glycoprotein (gD) binds to the HVEM receptor which is demanded by TNFSF14/LIGHT lowering the ability for LIGHT to activate the NFκB pathway. NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting caspase 8. When gD from HSV binds to HVEM, LIGHT is non-competitively inhibited from binding, encouraging apoptosis in the infected cell.

Specifications

Catalog number

HA500384

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CD 258 antibody CD258 antibody CD258 antigen antibody Delta transmembrane LIGHT antibody Herpes virus entry mediator ligand antibody Herpesvirus entry mediator A antibody Herpesvirus entry mediator ligand antibody herpesvirus entry mediator-ligand antibody HVEM L antibody HVEM-L antibody HVEML antibody Ligand for herpesvirus entry mediator antibody LIGHT antibody LTg antibody soluble form antibody TNF14 antibody TNF14_HUMAN antibody TNFSF 14 antibody Tnfsf14 antibody TNFSF14 protein antibody TR 2 antibody TR2 antibody Tumor necrosis factor (ligand) superfamily, member 14 antibody Tumor necrosis factor ligand superfamily member 14 antibody Tumor necrosis factor ligand superfamily, member 14 antibody Tumor necrosis factor receptor like 2 antibody tumor necrosis factor receptor-like 2 antibody Tumor necrosis factor superfamily member 14 antibody Tumor necrosis factor superfamily member LIGHT antibody

Abbreviation

Tumor necrosis factor ligand superfamily member 14 Herpes virus entry mediator ligand HVEM-L Herpesvirus entry mediator ligand CD258 TNFSF14 HVEML LIGHT UNQ391 PRO726

Swiss Prot

O43557 Human, Q9QYH9 Mouse

Cellular Locus

Cell membrane, Secreted, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within human TNFSF14 aa 190-240.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

Mouse liver tissue lysates, human liver tissue, human colon tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IHC-P: 1:600

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 26 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No