PSMB10 Rabbit Polyclonal Antibody

About this product

Proteasome subunit beta type-10 as known as 20S proteasome subunit beta-2i is a protein that in humans is encoded by the PSMB10 gene. This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and formed by replacing constitutive beta subunits with inducible beta subunits which possess specific cleavage properties that aid in the release of peptides necessary for MHC class I antigen presentation. The immunoproteasome appears to have a pivotal role in modulating NFκB signaling. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. The proteasomes form a pivotal component for the ubiquitin–proteasome system (UPS) and corresponding cellular Protein Quality Control (PQC). Protein ubiquitination and subsequent proteolysis and degradation by the proteasome are important mechanisms in the regulation of the cell cycle, cell growth and differentiation, gene transcription, signal transduction and apoptosis. During the antigen processing for the major histocompatibility complex (MHC) class-I, the proteasome is the major degradation machinery that degrades the antigen and present the resulting peptides to cytotoxic T lymphocytes. The immunoproteasome has been considered playing a critical role in improving the quality and quantity of generated class-I ligands.

Specifications

Catalog number

HA500393

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

beta2i antibody FLJ00366 antibody LMP10 antibody Low molecular mass protein 10 antibody Macropain subunit MECl 1 antibody Macropain subunit MECl-1 antibody MECL1 antibody MGC1665 antibody Multicatalytic endopeptidase complex subunit MECl 1 antibody Multicatalytic endopeptidase complex subunit MECl-1 antibody OTTHUMP00000174858 antibody Proteasome (prosome macropain) subunit beta type 10 antibody Proteasome beta 10 subunit antibody Proteasome catalytic subunit 2i antibody Proteasome MECl 1 antibody Proteasome MECl-1 antibody Proteasome subunit beta 2i antibody Proteasome subunit beta 7i antibody Proteasome subunit beta type 10 antibody Proteasome subunit beta type-10 antibody Proteasome subunit beta-2i antibody Proteasome subunit MECL1 antibody PSB10_HUMAN antibody PSMB 10 antibody Psmb10 antibody

Abbreviation

Proteasome subunit beta type-10 Low molecular mass protein 10 Macropain subunit MECl-1 Multicatalytic endopeptidase complex subunit MECl-1 Proteasome MECl-1 Proteasome subunit beta-2i PSMB10 LMP10 MECL1

Swiss Prot

P40306 Human, O35955 Mouse

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within huaman PSMB10 aa 40-273.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

Raji cell lysate, Daudi cell lysate, mouse colon tissue, SH-SY5Y.

Concentration

1.86 mg/mL

Dilution

WB: 1:500;IHC-P: 1:2,000;IF-Cell: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 29 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No