PSME2 Rabbit Polyclonal Antibody

About this product

Proteasome activator complex subunit 2 is a protein that in humans is encoded by the PSME2 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

Specifications

Catalog number

HA500394

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

11S regulator complex beta subunit antibody 11S regulator complex subunit beta antibody Activator of multicatalytic protease subunit 2 antibody Cell migration inducing protein 22 antibody MCP activator 31 kD subunit antibody PA28 beta antibody PA28b antibody PA28beta antibody Proteasome (prosome macropain) activator subunit 2 (PA28 beta) antibody Proteasome (prosome macropain) activator subunit 2 antibody Proteasome activator 28 beta antibody Proteasome activator 28 subunit beta antibody Proteasome activator complex subunit 2 antibody Proteasome activator hPA28 subunit beta antibody Proteasome activator subunit 2 antibody PSME 2 antibody PSME2 antibody PSME2_HUMAN antibody REG beta antibody REG-beta antibody REGbeta antibody

Abbreviation

Proteasome activator complex subunit 2 11S regulator complex subunit beta REG-beta Proteasome activator 28 subunit beta PA28b PA28beta PSME2

Swiss Prot

Q9UL46 Human, P97372 Mouse, Q63798 Rat

Cellular Locus

Cytosol, Extracellular region or secreted, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human aa 2-239.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell, FC

Positive Control

PC-12 cell lysate, Hela cell lysate, HepG2 cell lysate, PC-3M cell lysate, MCF-7 cell lysate, mouse thymus tissue lysate, rat thymus tissue lysate, human rectal carcinoma tissue, Hela, HepG2.

Concentration

1.6 mg/mL

Dilution

WB: 1:1,000;IHC-P: 1:800;IF-Cell: 1:100;FC: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 27 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No