PSMD8 Rabbit Polyclonal Antibody

About this product

26S proteasome non-ATPase regulatory subunit 8 is an enzyme that in humans is encoded by the PSMD8 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions. More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future.

Specifications

Catalog number

HA500408

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

26S proteasome non ATPase regulatory subunit 8 antibody 26S proteasome non-ATPase regulatory subunit 8 antibody 26S proteasome regulatory subunit p31 antibody 26S proteasome regulatory subunit RPN12 antibody 26S proteasome regulatory subunit S14 antibody AAV38494 antibody HIP6 antibody HYPF antibody MGC1660 antibody Nin1p antibody P31 antibody Proteasome (prosome macropain) 26S subunit non ATPase 8 antibody PSMD8 antibody PSMD8_HUMAN antibody Rpn12 antibody S14 antibody

Abbreviation

26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit RPN12 26S proteasome regulatory subunit S14 p31 PSMD8

Swiss Prot

P48556 Human, Q9CX56 Mouse, Q3B8P5 Rat

Cellular Locus

Cytosol. Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human PSMD8 aa 150-350.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell

Positive Control

A549 cell lysate, 293T cell lysate, NIH/3T3 cell lysate, Hela cell lysates, SiHa.

Concentration

2.31 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 40 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No