PSMD11 Rabbit Polyclonal Antibody

About this product

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF (BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF (BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF (BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF (BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. SCF (BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. Mediates ubiquitination of REST, thereby leading to its proteasomal degradation. SCF (BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity).

Specifications

Catalog number

HA500414

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

26S proteasome non-ATPase regulatory subunit 11 antibody 26S proteasome regulatory subunit 9 antibody 26S proteasome regulatory subunit p44.5 antibody 26S proteasome regulatory subunit RPN6 antibody 26S proteasome regulatory subunit S9 antibody MGC3844 antibody p44.5 antibody protease 26S, subunit, 9 antibody proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 antibody proteasome 26S subunit, non-ATPase, 11 antibody PSD11_HUMAN antibody PSMD 11 antibody PSMD11 antibody Rpn6 antibody S9 antibody

Abbreviation

F-box/WD repeat-containing protein 1A E3RSIkappaB Epididymis tissue protein Li 2a F-box and WD repeats protein beta-TrCP pIkappaBalpha-E3 receptor subunit BTRC BTRCP FBW1A FBXW1A

Swiss Prot

O00231 Human, Q8BG32 Mouse, F1LMZ8 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human PSMD11 aa 200-500.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

293T cell lysate, HepG2 cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, PC-3 cell lysate, Hela cell lysate, mouse testis tissue lysate, rat testis tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, mouse testis tissue, NIH/3T3.

Concentration

2 mg/mL

Dilution

WB: 1:2,000;IHC-P: 1:400;IF-Cell: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 47 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No