RYK Rabbit Polyclonal Antibody

About this product

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Specifications

Catalog number

HA500416

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

D3S3195 antibody ERK 3 antibody Hydroxyaryl protein kinase antibody JTK 5 antibody JTK 5A antibody JTK5 antibody JTK5A antibody JTK5A protein tyrosine kinase antibody receptor like tyrosine kinase antibody receptor like tyrosine kinase precursor antibody RYK 1 antibody Ryk antibody RYK_HUMAN antibody RYK1 antibody Tyrosine protein kinase RYK antibody Tyrosine protein kinase RYK precursor antibody Tyrosine-protein kinase RYK antibody Vik antibody

Abbreviation

Tyrosine-protein kinase RYK RYK JTK5A

Swiss Prot

P34925 Human, Q01887 Mouse,

Cellular Locus

Cytoplasm, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human RYK aa 300-550.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

SH-SY5Y cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, MCF-7 cell lysates, NIH/3T3, SH-SY5Y.

Concentration

1.777 mg/mL

Dilution

WB: 1:500-1:10,000;IF-Cell: 1:200;FC: 1:500-1:1,000

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No