Naked1 Rabbit Polyclonal Antibody

Catalog number HA500419

Price for HA500419

Size / count 100 µL

About this product

Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3). Nkd1 binds to the Dishevelled (Dvl) family of proteins (DVL1, DVL2, DVL3). Specific truncating NKD1 mutations identified in DNA mismatch repair deficient colon cancer that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in approximately 1% of human colon cancer, the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes.

Specifications

Catalog number: HA500419
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Dvl-binding protein antibody Naked cuticle 1 antibody naked cuticle 1 homolog antibody Naked cuticle homolog 1 (Drosophila) antibody Naked-1 antibody NKD antibody Nkd1 antibody Protein naked cuticle homolog 1 antibody
Abbreviation: Protein naked cuticle homolog 1 Naked-1 hNkd hNkd1 NKD1 NKD PP7246
Swiss Prot: Q969G9 Human, Q99MH6 Mouse,
Cellular Locus: Cell membrane, Cytoplasm, Membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within human Naked1 aa 30-100.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P, IF-Cell
Positive Control: HepG2 cell lysate, HCT116 cell lysate, 293 cell lysate, SH-SY5Y cell lysate, rat smooth muscle tissue, mouse smooth muscle tissue, SH-SY5Y.
Concentration: 2.107 mg/mL
Dilution: WB: 1:500;IHC-P: 1:400;IF-Cell: 1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 52 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Naked1 Rabbit Polyclonal Antibody?

The catalog number for Naked1 Rabbit Polyclonal Antibody is HA500419.

What sizes are available for Naked1 Rabbit Polyclonal Antibody?

Naked1 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is Naked1 Rabbit Polyclonal Antibody in stock?

Naked1 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is Naked1 Rabbit Polyclonal Antibody used for?

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.