RAC1/2/3 Rabbit Polyclonal Antibody

About this product

Rac1 function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac2 fucntion: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Rac3 function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.

Specifications

Catalog number

HA500424

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

OTTMUSP00000004488 antibody p21 Rac3 antibody p21-Rac3 antibody Rac1B antibody RAC3 antibody RAC3_HUMAN antibody RAS related C3 botulinum substrate 3 antibody Ras related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3) antibody Ras related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) antibody Ras-related C3 botulinum toxin substrate 3 antibody Rho family small GTP binding protein Rac3 antibody RP23-84C12.18 antibody

Abbreviation

RAC3

Swiss Prot

P15153 Human, P60763 Human, P63000 Human, P60764 Mouse, P63001 Mouse, Q05144 Mouse,

Cellular Locus

Cytoplasm, Cytoplasm, Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human RAC3 aa 23-192 / 192.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

Rat brain tissue lysate, human brain tissue lysate, rat skin tissue, SH-SY5Y, mouse brain tissue lysate, mouse cerebellum tissue lysate.

Concentration

1.958 mg/mL

Dilution

WB: 1:500;IHC-P: 1:600;IF-Cell: 1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 21 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No