TRPM2 Rabbit Polyclonal Antibody

About this product

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene. The TRPM2 gene is highly expressed in the brain and was implicated by both genetic linkage studies in families and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder (Manic Depression). The physiological role of TRPM2 is not well understood. It was shown to be involved in insulin secretion.[5][11] In the immune cells it mediates parts of the responses to TNF-alpha. A role has been suggested for TRPM2 in activation of NLRP3 inflammasome, the dysregulation of which is strongly associated with a number of auto inflammatory and metabolic diseases, such as gout, obesity and diabetes.[13] In the brain it is involved in the toxicity of amyloid beta, a protein associated with Alzheimer's disease.[14] In 2016, TRPM2 channel was strongly implicated in the detection of non-painful warm stimuli. Chun-Hsiang Tan and Peter McNaughton studied the responses of actual sensory neurons to thermal stimuli, then used an RNA-sequencing strategy to identify TRPM2 as genetically required for warmth detection in the non-noxious range of 33–38°C.

Specifications

Catalog number

HA500437

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

EREG 1 antibody EREG1 antibody Estrogen responsive element associated gene 1 antibody Estrogen responsive element associated gene 1 protein antibody Estrogen-responsive element-associated gene 1 protein antibody KNP 3 antibody KNP3 antibody Long transient receptor potential channel 2 antibody LTRPC 2 antibody LTrpC-2 antibody LTrpC2 antibody MGC133383 antibody NUDT9H antibody NUDT9L1 antibody putative Ca2+ channel protein antibody putative Ca2+ channel protein antibody Transient receptor potential cation channel subfamily M member 2 antibody Transient receptor potential channel 7 antibody TRPC 7 antibody TrpC7 antibody TRPM 2 antibody Trpm2 antibody TRPM2_HUMAN antibody

Abbreviation

TRPM2

Swiss Prot

O94759 Human, Q91YD4 Mouse, Q5G856 Rat

Cellular Locus

Lysosome, cell membrane, perikaryon, cell projection, cytoplasmic vesicle.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within mouse TRPM2 aa 100-150 / 1503 (Cytoplasmic).

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

THP-1 cell lysate, PC-3 cell lysate, rat cerebellum tissue, human bone tissue, mouse brain tissue, SH-SY5Y.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC:1:100-1:500

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

172 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No