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Product details
Catalog number HA500470
Price for HA500470
Size / count 100 µL
The history of the Onecut (Oc) family of transcription factors begins, as does the history of many transcription factors, in Drosophila. Work carried out by Jan and colleagues discovered that mutations in the cut locus in Drosophila resulted in the transformation of external sensory organs into chordotonal organs during embryonic development. This unique family of transcription factors has an important role in the development of several different organs. The endodermally-derived hepatobiliary tract as well as the pancreas both rely on the Oc factors for proper differentiation of many mature cell types. A role for the Oc factors in neuronal development has been identified in many model systems indicating an important conserved function. While the discovery of the cut locus in Drosophila indicated its function in differentiation of the external sensory organs, the protein produced from that locus in fact contained three cut repeats. A paralog of mammalian Oc1 was identified in Drosophila named D-Onecut, role which has a unique in regulation of photoreceptor cell differentiation. Indeed, Oc orthologs regulate neural cell specification and differentiation in ascidians, zebrafish, Xenopus and C. elegans. Thus, the various cell types of the nervous system may represent the broadest and most diverse population where the Oc factors regulate cell lineage specification and differentiation.
The catalog number for OC-3 Rabbit Polyclonal Antibody is HA500470.
OC-3 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.
OC-3 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.
The history of the Onecut (Oc) family of transcription factors begins, as does the history of many transcription factors, in Drosophila. Work carried out by Jan and colleagues discovered that mutations in the cut locus in Drosophila resulted in the transformation of external sensory organs into chor
Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.
Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.
Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.
