MYL4 Rabbit Polyclonal Antibody — image 1 of 3

Product details

MYL4 Rabbit Polyclonal Antibody

Catalog number HA500471

Price for HA500471

Size / count 100 µL

About this product

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases. ALC-1 is expressed very early in skeletal muscle and cardiac muscle development; two E-boxes and CArG box in the MYL4 promoter region regulate transcription. ALC-1 expression in cardiac ventricles decreases in early postnatal development, but is highly expressed in atria throughout all of adulthood. Normal atrial function is essential for embryogenesis, as inactivation of the MYL7 gene was embryonic lethal at ED10.5-11.5. Evidence of ALC-1 isoform expression on contractile mechanics of sarcomeres came from experiments studying fibers from patients expressing a higher level of ALC-1 relative to VLC-1 in cardiac left ventricular tissue.

Specifications

Catalog number: HA500471
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: ALC 1 antibody ALC1 antibody AMLC antibody Atrial/embryonic alkali myosin light chain antibody embryonic muscle/atrial isoform antibody GT 1 antibody GT1 antibody MLC 1 antibody MLC1 antibody MYL 4 antibody Myl4 antibody MYL4_HUMAN antibody Myosin atrial/fetal muscle light chain antibody Myosin light chain 1 antibody Myosin light chain 1 embryonic muscle/atrial isoform antibody Myosin light chain 4 alkali atrial embryonic antibody Myosin light chain 4 antibody Myosin light chain alkali GT 1 isoform antibody Myosin light chain alkali GT-1 isoform antibody Myosin light polypeptide 4 alkali atrial embryonic antibody Myosin light polypeptide 4 antibody PRO1957 antibody
Abbreviation: MYL4
Swiss Prot: P12829 Human, P09541 Mouse, P17209 Rat
Cellular Locus: Myosin complex, cytosol, A band.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within human MYL4 aa 10-197 / 197.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P
Positive Control: Mouse lung tissue lysate, human heart tissue lysate, rat lung tissue, rat heart tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:200-1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 22 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for MYL4 Rabbit Polyclonal Antibody?

The catalog number for MYL4 Rabbit Polyclonal Antibody is HA500471.

What sizes are available for MYL4 Rabbit Polyclonal Antibody?

MYL4 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is MYL4 Rabbit Polyclonal Antibody in stock?

MYL4 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is MYL4 Rabbit Polyclonal Antibody used for?

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.