TRIM33 Rabbit Polyclonal Antibody

About this product

The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.

Specifications

Catalog number

HA500475

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

8030451N04Rik antibody AI413936 antibody cb1085 antibody DKFZp586K1123 antibody E3 ubiquitin-protein ligase TRIM33 antibody EC 6.3.2.- antibody Ectodermin antibody Ectodermin homolog antibody FLJ11429 antibody FLJ32925 antibody id:ibd2175 antibody MGC136680 antibody mKIAA1113 antibody OTTHUMP00000013662 antibody OTTHUMP00000013663 antibody Protein Rfg7 antibody PTC7 antibody Ret fused gene 7 antibody RET-fused gene 7 protein antibody RFG7 antibody Rfg7 protein antibody TF1G antibody TIF1 gamma antibody TIF1-gamma antibody TIF1G antibody TIF1GAMMA antibody TIFGAMMA antibody Transcription intermediary factor 1-gamma antibody Transcriptional intermediary factor 1 gamma antibody TRI33_HUMAN antibody trim33 antibody Tripartite motif containing 33 antibody Tripartite motif containing 33 protein antibody tripartite motif-containing 33 antibody Tripartite motif-containing protein 33 antibody wu:fc17f10 antibody zgc:136680 antibody

Abbreviation

TRIM33

Swiss Prot

Q9UPN9 Human, Q99PP7 Mouse

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant protein within human TRIM33 aa 900-1127 / 1127.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P

Positive Control

K562 cell lysates, mouse uterus tissue lysates, human placenta tissue, human thyroid tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

123 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No