RNF111 Rabbit Polyclonal Antibody — image 1 of 2

Product details

RNF111 Rabbit Polyclonal Antibody

Catalog number HA500485

Price for HA500485

Size / count 100 µL

About this product

E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development. Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded. Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL. Associates with UBE2D2 as an E2 enzyme. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates. Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair. Mediates ubiquitination and degradation of sumoylated PML. The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs).

Specifications

Catalog number: HA500485
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: BCA2 antibody Breast cancer associated gene 2 antibody CL469780 antibody E3 ubiquitin-protein ligase RNF115 antibody Rabring 7 antibody RING finger protein 115 antibody RN115_HUMAN antibody RNF115 antibody Zinc finger protein 364 antibody ZNF364 antibody
Abbreviation: RNF111
Swiss Prot: Q6ZNA4 Human
Cellular Locus: Cytoplasm, Nucleus, PML body.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within human RNF111 aa 795-994 / 994.
Isotype: IgG
Conjugation: Non-conjugated
Type: Rabbit polyclonal Antibody
Applications: WB, IHC-P, FC
Positive Control: K562 cell lysate, 293T cell lysate, Hela cell lysate, human placenta tissue, Hela.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:500-1:1,000
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 109 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for RNF111 Rabbit Polyclonal Antibody?

The catalog number for RNF111 Rabbit Polyclonal Antibody is HA500485.

What sizes are available for RNF111 Rabbit Polyclonal Antibody?

RNF111 Rabbit Polyclonal Antibody is available in the following size(s): 100 µL.

Is RNF111 Rabbit Polyclonal Antibody in stock?

RNF111 Rabbit Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

What is RNF111 Rabbit Polyclonal Antibody used for?

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.