Hamartin Mouse Monoclonal Antibody [A6F1] — image 1 of 3

Product details

Hamartin Mouse Monoclonal Antibody [A6F1]

Catalog number HA600004

Price for HA600004

Size / count 100 µL

About this product

Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene. TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex has been implicated as a tumor suppressor. Defects in this gene can cause tuberous sclerosis, due to a functional impairment of the TSC complex. Defects in TSC1 may also be a cause of focal cortical dysplasia. TSC1 may be involved in protecting brain neurons in the CA3 region of the hippocampus from the effects of stroke.

Specifications

Catalog number: HA600004
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Hamartin antibody kiaa0243 antibody LAM antibody TSC antibody Tsc1 antibody Tsc1 gene antibody TSC1_HUMAN antibody Tuberous sclerosis 1 antibody Tuberous sclerosis 1 protein antibody tumor suppressor antibody
Abbreviation: TSC1
Swiss Prot: Q92574 Human, Q9EP53 Mouse
Cellular Locus: Cytoplasm, Membrane.
Host: Mouse
Species Reactivity: Human, Mouse
Immunogen: Recombinant protein within human Hamartin aa 401-600.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, IF-Cell, IHC-P, FC
Positive Control: Hela cell lysate, 293 cell lysate, NIH/3T3 cell lysate, Hela, NIH/3T3, human kidney tissue, human fetal skeletal muscle tissue, PC-3.
Concentration: 2 mg/mL
Dilution: WB: 1:500;IF-Cell: 1:100;IHC-P: 1:200-1:600;FC: 1:500-1:1,000
Purity: Protein G affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 130 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for Hamartin Mouse Monoclonal Antibody [A6F1]?

The catalog number for Hamartin Mouse Monoclonal Antibody [A6F1] is HA600004.

What sizes are available for Hamartin Mouse Monoclonal Antibody [A6F1]?

Hamartin Mouse Monoclonal Antibody [A6F1] is available in the following size(s): 100 µL.

Is Hamartin Mouse Monoclonal Antibody [A6F1] in stock?

Hamartin Mouse Monoclonal Antibody [A6F1] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Hamartin Mouse Monoclonal Antibody [A6F1] used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.