Iba1 Recombinant Antibody [A5C6] - Human IgG1 (Chimeric)

About this product

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells. This human monoclonal chimeric antibody has been engineered from the mouse monoclonal parent antibody. By necessity, some mouse sequence is retained as part of the variable domain. When multiplexing with other mouse-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended.

Specifications

Catalog number

HA600012

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Cell surface glycoprotein Trop 2 antibody Cell surface glycoprotein Trop-2 antibody Cell surface glycoprotein Trop2 antibody Epithelial glycoprotein 1 antibody GA733 1 antibody GA7331 antibody M1S 1 antibody M1S1 antibody Membrane component chromosome 1 surface marker 1 antibody Pancreatic carcinoma marker protein GA733 1 antibody Pancreatic carcinoma marker protein GA733-1 antibody Pancreatic carcinoma marker protein GA7331 antibody TACD 2 antibody TACD2_HUMAN antibody TACSTD 2 antibody Tacstd2 antibody Trop 2 antibody Trop2 antibody Tumor associated calcium signal transducer 2 precursor antibody Tumor-associated calcium signal transducer 2 antibody

Abbreviation

Tumor-associated calcium signal transducer 2 Cell surface glycoprotein Trop-2 Membrane component chromosome 1 surface marker 1 Pancreatic carcinoma marker protein GA733-1

Swiss Prot

P09758 Human

Cellular Locus

Membrane.

Species Reactivity

Human

Immunogen

Recombinant protein within Human TROP2 aa27-274 (Extracellular) in HEK293 cell.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Recombinant Chimeric Antibody Antibody

Applications

ELISA, FC

Positive Control

Recombinant TROP2 protein, MDA-MB-468 cell.

Concentration

1 mg/mL

Dilution

ELISA: 1:5,000-1:20,000 ;FC: 1:100-1:200

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4).

Molecular Weight

35.7 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes