Cytokeratin 18 Mouse Monoclonal Antibody [A4B4]

About this product

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Cytokeratins 8 and 18 (CK8/18) make up one of the low molecular weight cytokeratins (LMW-CK). CK8/18 is expressed in simple, non-stratified epithelia, basal and superficial cells of transitional epithelium, the luminal/secretory cells of complex epithelia, mesothelium, and may be present in some types of mesenchymal cells. Multiple cytokeratins family members may be expressed in a given cell and are characteristic of the cell type and differentiation state. Nearly all carcinomas of epithelial origin and mesotheliomas express CK8/18, and CK8/18 expression patterns aid in the classification of tumors of unknown origin and poorly differentiated carcinomas. Antibodies to CK8/18 may be useful for classification of tumors of epithelial origin.

Specifications

Catalog number

HA600020

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Cell proliferation inducing gene 46 protein antibody Cell proliferation inducing protein 46 antibody Cell proliferation-inducing gene 46 protein antibody CK 18 antibody CK-18 antibody CK18 antibody CYK 18 antibody CYK18 antibody Cytokeratin 18 antibody Cytokeratin endo B antibody Cytokeratin-18 antibody K 18 antibody K18 antibody K1C18_HUMAN antibody KA18 antibody Keratin 18 antibody Keratin 18, type I antibody Keratin D antibody keratin, type I cytoskeletal 18 antibody Keratin-18 antibody Krt18 antibody

Abbreviation

KRT18

Swiss Prot

P05783 Human

Cellular Locus

Nucleolus, perinuclear region.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within human Cytokeratin 18 aa 1-150.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

SK-Br-3 cell lysate, A549 cell lysate, human liver tissue, human skin tissue, human prostate carcinoma tissue, human breast carcinoma tissue, MCF-7.

Concentration

2 mg/mL

Dilution

WB:1:500-1:2,000 ;IHC-P:1:100-1:500 ;FC:1:50-1:100

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 48 kDa.

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No