IGF1R Mouse Monoclonal Antibody [D5-G2] — image 1 of 2

Product details

IGF1R Mouse Monoclonal Antibody [D5-G2]

Catalog number HA600033

Price for HA600033

Size / count 100 µL

About this product

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.

Specifications

Catalog number: HA600033
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Insulin-like growth factor 1 receptor beta chain antibody CD221 antibody CD221 antigen antibody IGF 1 receptor antibody IGF 1R antibody IGF I receptor antibody IGF-I receptor antibody Igf1r antibody IGF1R_HUMAN antibody IGFIR antibody IGFIRC antibody IGFR antibody Insulin like growth factor 1 receptor antibody Insulin like growth factor 1 receptor precursor antibody Insulin-like growth factor 1 receptor beta chain antibody Insulin-like growth factor I receptor antibody JTK13 antibody MGC142170 antibody MGC142172 antibody MGC18216 antibody Soluble IGF1R variant 1 antibody Soluble IGF1R variant 2 antibody
Abbreviation: Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF-I receptor CD221 Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain
Swiss Prot: P08069 Human
Cellular Locus: Cell membrane, Membrane.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within human IGF1R aa 600-1000.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: WB, FC
Positive Control: 293 cell lysates, SiHa.
Concentration: 2 mg/mL
Dilution: WB: 1:500 ;FC: 1:50-1:100
Purity: Protein G affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 155 kDa.
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for IGF1R Mouse Monoclonal Antibody [D5-G2]?

The catalog number for IGF1R Mouse Monoclonal Antibody [D5-G2] is HA600033.

What sizes are available for IGF1R Mouse Monoclonal Antibody [D5-G2]?

IGF1R Mouse Monoclonal Antibody [D5-G2] is available in the following size(s): 100 µL.

Is IGF1R Mouse Monoclonal Antibody [D5-G2] in stock?

IGF1R Mouse Monoclonal Antibody [D5-G2] is currently made to order / not held in immediate stock. Contact us for lead time.

What is IGF1R Mouse Monoclonal Antibody [D5-G2] used for?

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.