RUNX3 Mouse Monoclonal Antibody [A7B7]

About this product

Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene. This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. In melanocytic cells RUNX3 gene expression may be regulated by MITF. Most of this literature used RUNX3 promoter methylation status in various cancers as a proxy for its expression. However, quite many genes are known to be methylated in tumor cell genomes, and the majority of these genes are not expressed in the normal tissue of origin of these cancers.

Specifications

Catalog number

HA600058

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Acute myeloid leukemia 2 protein antibody Acute myeloid leukemia gene 2 antibody AML 2 antibody AML2 antibody CBF alpha 3 antibody CBF-alpha-3 antibody CBFA 3 antibody CBFA3 antibody Core binding factor alpha 3 subunit antibody core binding factor antibody Core binding factor runt domain alpha subunit 3 antibody Core binding factor subunit alpha 3 antibody core-binding factor antibody Core-binding factor subunit alpha-3 antibody Oncogene AML 2 antibody Oncogene AML-2 antibody PEA2 alpha C antibody PEA2-alpha C antibody PEBP2 alpha C antibody PEBP2-alpha C antibody Pebp2a3 antibody PEBP2aC antibody Polyomavirus enhancer binding protein 2 alpha C subunit antibody Polyomavirus enhancer-binding protein 2 alpha C subunit antibody runt domain alpha subunit 3 antibody runt related transcription factor 3 antibody Runt-related transcription factor 3 antibody RUNX 3 antibody Runx3 antibody RUNX3_HUMAN antibody SL3 3 enhancer factor 1 alpha C subunit antibody SL3-3 enhancer factor 1 alpha C subunit antibody SL3/AKV core binding factor alpha C subunit antibody SL3/AKV core-binding factor alpha C subunit antibody Transcription factor AML2 antibody

Abbreviation

RUNX3

Swiss Prot

Q13761 Human, Q91ZK1 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Mouse

Species Reactivity

Human, Rat

Immunogen

Recombinant protein within human RUNX3 aa 151-350/415.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IHC-P

Positive Control

SW480 cell lysates, Raji cell lysates, rat large intestine tissue, human tonsils tissue, human colon tissue.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:200-1:600

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 44 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No