ACVR2B Mouse Monoclonal Antibody [A5H6]

About this product

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Specifications

Catalog number

HA600066

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

Activin A receptor type IIB antibody Activin receptor type 2B antibody Activin receptor type IIB antibody Activin receptor type-2B antibody ActR IIB antibody ACTR-IIB antibody ActRIIB antibody ACVR 2B antibody ACVR2B antibody AVR2B_HUMAN antibody HTX4 antibody MGC116908 antibody

Abbreviation

ACVR2B

Swiss Prot

Q13705 Human, P27040 Mouse, P38445 Rat, Q9YGU4 Zebrafish

Cellular Locus

Cell membrane.

Host

Mouse

Species Reactivity

Human, Mouse, Rat, Zebrafish

Immunogen

Synthetic peptide within human ACVR2B aa 331-380 / 512.

Isotype

IgG2a

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB

Positive Control

Hela cell lysates.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000

Purity

Protein G affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

58 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No