BCL6 Mouse Monoclonal Antibody [A6C7]

Catalog number HA600096

Price for HA600096

Size / count 100 µL

About this product

The Bcl-6 protein (B-cell CLL/lymphoma 6, zinc finger protein 51) is a nuclear zinc finger transcription factor with an N-terminal POZ domain. Bcl-6 represses p53 transcription by binding 2 specific DNA sites within the p53 promoter region and accordingly, p53 expression is absent in germinal centre B-cells where Bcl-6 is highly expressed. Most notably, constitutive expression of Bcl-6 protects B-cell lines from apoptosis induced by DNA damage. Bcl-6 is mainly used in the classification of B-cell lymphomas. In malignant lymphomas, Bcl-6 protein is most commonly detected in germinal centre neoplasms including follicular lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma (40%), lymphocyte predominant Hodgkin lymphoma, and even in peripheral T-cell lymphoma with follicular localization (“follicular T cell lymphoma”). It is also found in CD30+ anaplastic large cell lymphoma. Bcl-6 expression is virtually absent in acute lymphatic leukaemia and mantle cell lymphoma. Normal tonsil is recommended as positive and negative tissue control. Virtually all the germinal centre B-cells must show a moderate to strong nuclear staining reaction, while an at least weak to moderate nuclear staining reaction must be seen in the majority of squamous epithelial cells. In the mantle zones and interfollicular areas only dispersed cells should display a positive nuclear staining reaction.

Specifications

Catalog number: HA600096
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: B cell CLL/lymphoma 6 antibody B cell lymphoma 6 protein antibody B-cell lymphoma 5 protein antibody B-cell lymphoma 6 protein antibody BCL 5 antibody Bcl 6 antibody BCL-5 antibody BCL-6 antibody BCL5 antibody BCL6 antibody BCL6_HUMAN antibody BCL6A antibody cys his2 zinc finger transcription factor antibody cys-his2 zinc finger transcription factor antibody LAZ 3 antibody LAZ 3 protein antibody LAZ3 antibody Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) antibody Lymphoma associated zinc finger gene on chromosome 3 antibody Protein LAZ-3 antibody ZBTB 27 antibody ZBTB27 antibody Zinc finger and BTB domain containing protein 27 antibody Zinc finger and BTB domain-containing protein 27 (ZBTB27) antibody Zinc finger and BTB domain-containing protein 27 antibody Zinc Finger Protein 51 (ZNF51) antibody Zinc finger protein 51 antibody zinc finger transcription factor BCL6S antibody ZNF 51 antibody ZNF51 antibody
Abbreviation: BCL6
Swiss Prot: P41182 Human
Cellular Locus: Nucleus.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human BCL-6 aa 301-500 / 706.
Isotype: IgG1
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: IHC-P, IF-Cell
Positive Control: Human lymph nodes tissue, human B lymphocytoma tissue, Raji.
Concentration: 2 mg/mL
Dilution: IHC-P: 1:500 ;IF-Cell: 1:200
Purity: Immunogen affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 79 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for BCL6 Mouse Monoclonal Antibody [A6C7]?

The catalog number for BCL6 Mouse Monoclonal Antibody [A6C7] is HA600096.

What sizes are available for BCL6 Mouse Monoclonal Antibody [A6C7]?

BCL6 Mouse Monoclonal Antibody [A6C7] is available in the following size(s): 100 µL.

Is BCL6 Mouse Monoclonal Antibody [A6C7] in stock?

BCL6 Mouse Monoclonal Antibody [A6C7] is currently made to order / not held in immediate stock. Contact us for lead time.

What is BCL6 Mouse Monoclonal Antibody [A6C7] used for?

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.