Prolactin Receptor Mouse Monoclonal Antibody [A6E4]

About this product

The prolactin receptor (PRLR) is a type I cytokine receptor encoded in humans by the PRLR gene on chromosome 5p13-14. It is the receptor for prolactin (PRL). The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL). The PRLR is expressed in the mammary glands, pituitary gland, and other tissues. It plays an important role in lobuloalveolar development of the mammary glands during pregnancy and in lactation. The PRLR is a class 1 cytokine receptor that uses messenger pathways to control cell proliferation, migration, intracellular ion concentration and inhibit programmed cell death (apoptosis). Expression of the PRLR protein is found within cells of the mammary glands[10] in accordance with its role in lactation, but also is the subject of attention for its diverse and emerging roles by its expression in adipose tissue, pancreatic islet cell proliferation, and immune responses. The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures. Disruption of PRLR signaling pathways have been linked to tumorigenesis and breast cancer development.

Specifications

Catalog number

HA600099

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

AI987712 antibody CLONE SPM213 antibody CPRLP antibody Delta 4-delta 7/11 truncated prolactin receptor antibody Delta 4-SF1b truncated prolactin receptor antibody HPRL antibody hPRL receptor antibody hPRLrI antibody Lactogen receptor antibody MFAB antibody MGC105486 antibody OPR antibody OTTHUMP00000115998 antibody Pr-1 antibody Pr-3 antibody PRL R antibody PRL-R antibody PRLR antibody Prlr-rs1 antibody PRLR_HUMAN antibody Prolactin receptor a antibody Prolactin receptor antibody Prolactin receptor delta 7/11 antibody RATPRLR antibody Secreted prolactin binding protein antibody Truncated testis-specific box 1-C prolactin receptor antibody wu:fj65c07 antibody

Abbreviation

PRLR

Swiss Prot

P16471 Human

Cellular Locus

Membrane, Secreted.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within Human Prolactin Receptor aa 150-350 / 622.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

293T cell lysate, Hela cell lysate, MCF-7, human kidney tissue, human pancreas tissue, HeLa.

Concentration

2 mg/mL

Dilution

WB: 1:500 ;IF-Cell: 1:100 ;IHC-P: 1:200 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 70 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No