- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
![iFluor™ 488 Conjugated Beta III Tubulin Mouse Monoclonal Antibody [A8-D10] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea8236d/imageurl/ha600106f.webp)
Select the image to view it full size.
Product details
Catalog number HA600106F
Price for HA600106F
Size / count 100 µL
Class III β-tubulin, otherwise known as βIII-tubulin (β3-tubulin) or β-tubulin III, is a microtubule element of the tubulin family. In humans, it is encoded by the TUBB3 gene. It is possible to use monoclonal antibodies and immunohistochemistry to identify neurons in samples of brain tissue, separating neurons from glial cells, which do not express Class III β-tubulin. Class III β-tubulin is one of the seven β-tubulin isotypes identified in the human genome, predominantly in neurons and the testis. It is conditionally expressed in a number of other tissues after exposure to a toxic microenvironment featured by hypoxia and poor nutrient supply. Posttranslational changes including phosphorylation and glycosylation are required for functional activity. Class III β-tubulin’s role in neural development has warranted its use as an early biomarker of neural cell differentiation from multi potent progenitors. TUBB3 inactivation impairs neural progenitor proliferation. Rescue experiments demonstrate the non-interchangeability of TUBB3 with other classes of β-tubulins which cannot restore the phenotype resulting from TUBB3 inactivation. Congenital neurologic syndromes associated with TUBB3 missense mutations demonstrate the critical importance of class III β-tubulin for normal neural development. Overexpression of class III beta tubulin is associated with the resistances of microtubule-targeted cancer drugs in lung cancer cell lines, breast cancer cell lines, and ovarian tumors.
The catalog number for iFluor™ 488 Conjugated Beta III Tubulin Mouse Monoclonal Antibody [A8-D10] is HA600106F.
iFluor™ 488 Conjugated Beta III Tubulin Mouse Monoclonal Antibody [A8-D10] is available in the following size(s): 100 µL.
iFluor™ 488 Conjugated Beta III Tubulin Mouse Monoclonal Antibody [A8-D10] is currently made to order / not held in immediate stock. Contact us for lead time.
Class III β-tubulin, otherwise known as βIII-tubulin (β3-tubulin) or β-tubulin III, is a microtubule element of the tubulin family. In humans, it is encoded by the TUBB3 gene. It is possible to use monoclonal antibodies and immunohistochemistry to identify neurons in samples of brain tissue, separat
Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.
If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.
The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.
