CD64 Mouse Monoclonal Antibody [A7E4]

About this product

CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1. These three genes produce six different mRNA transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.

Specifications

Catalog number

HA601003

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Product Name Alternative

CD 64 antibody CD64 antibody CD64 antigen antibody CD64A antibody CD64b antibody CD64c antibody Fc fragment of IgG high affinity Ia receptor antibody Fc fragment of IgG high affinity Ib receptor antibody Fc fragment of IgG high affinity Ic receptor antibody Fc fragment of IgG, high affinity Ia, receptor (CD64) antibody Fc fragment of IgG, high affinity Ia, receptor for (CD64) antibody Fc fragment of IgG, high affinity Ia, receptor for antibody Fc fragment of IgG, high affinity Ib, receptor (CD64) antibody Fc fragment of IgG, high affinity Ib, receptor for antibody Fc fragment of IgG, high affinity Ic, receptor (CD64) antibody Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene antibody Fc fragment of IgG, high affinity Ic, receptor for antibody Fc gamma receptor antibody Fc gamma receptor I A1 antibody Fc gamma receptor I antibody Fc gamma receptor I B2 antibody Fc gamma RI antibody Fc gamma RIA antibody Fc gamma RIB antibody Fc of IgG high affinity Ia receptor antibody Fc-gamma RI antibody Fc-gamma RIA antibody Fc-gamma RIC antibody FCG 1 antibody FCG1 antibody FcgammaRI antibody FcgammaRIa antibody FCGR 1 antibody FCGR1 antibody FCGR1_HUMAN antibody FCGR1A antibody FCGR1B antibody FCGR1C antibody FcRI antibody FcRIB antibody FCRIC antibody FLJ18345 antibody HFcgammaRIB antibody High affinity immunoglobulin gamma Fc receptor I antibody High affinity immunoglobulin gamma Fc receptor IB antibody IGFR 1 antibody IGFR1 antibody IGFRB antibody IGFRC antibody IgG Fc receptor I antibody IgG Fc receptor IB antibody IgG Fc receptor IC antibody Immunoglobulin G Fc receptor I antibody Immunoglobulin G Fc receptor IB antibody Immunoglobulin G Fc receptor IC antibody MGC137713 antibody

Abbreviation

FCGR1A

Swiss Prot

P12314 Human

Cellular Locus

Cell membrane.

Host

Mouse

Species Reactivity

Human

Immunogen

Recombinant protein within Human CD64 aa 1-200 / 374.

Isotype

IgG1

Conjugation

Non-conjugated

Type

Mouse monoclonal Antibody

Applications

WB

Positive Control

THP-1 cell lysates, U937 cell lysates.

Concentration

2 mg/mL

Dilution

WB: 1:500-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 43 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

No